Grote Zaal, 1st Floor
Thursday, May 4, 12:15 – 13:45
Management of early-stage HCC: current unmet needs and rationale for neoadjuvant and adjuvant immunotherapy-based approaches
12:15–12:25 WELCOME AND INTRODUCTION TO HCC, Gonzalo Sapisochin, MD, Toronto, Canada
12:25–12:40 CURRENT MANAGEMENT OF EARLY-STAGE AND INTERMEDIATE-STAGE HCC, Albert Chan, MD, Hong Kong
12:40–13:00 IMMUNOTHERAPY IN HCC: CURRENT LANDSCAPE AND POTENTIAL RATIONALE FOR NOVEL NEOADJUVANT AND ADJUVANT APPROACHES, Sherrie Bhoori, MD, Milan, Italy
13:00–13:15 CASE-STUDY DISCUSSION: MANAGEMENT OF HCC POTENTIALLY ELIGIBLE FOR TRANSPLANT, Parissa Tabrizian, MD, New York, USA
13:15–13:30 CASE-STUDY DISCUSSION: MANAGEMENT OF HCC THAT IS BORDERLINE MILAN CRITERIA, Gonzalo Sapisochin, MD, Toronto, Canada
13:30–13:45 AUDIENCE Q&A, Gonzalo Sapisochin, MD, Toronto, Canada

Jurriaanse Zaal, 1st Floor
Thursday, May 4, 15:15 – 16:15
Thriving post transplant – shaping the environment and therapy for long term success
15:15-15:25 Welcome and introductory remarks – Prof. Herold J Metselaar (Chair) Erasmus MC, Gastroenterology &  Hepatology, Netherlands
15:25-15:40 Artificial intelligence and liver transplantation – Dr. Javier Briceño, Hospital Universitario Reina Sofía, Spain
15:40-15:55 Current and future aspects of liver preservation and re-conditioning – Dr Alexandre Chebaro, CHU Rennes University Hospital, France
15:55-16:10 The importance of maintaining adequate tacrolimus levels. What’s new? – Dr. Rodríguez-Perálvarez, Hospital Universitario Reina Sofía, Spain
16:10-16:15 Concluding remarks – Prof. Herold J Metselaar (Chair)

Van Weelde Zaal, 4th Floor
Thursday, May 4, 15:15 – 16:15
Liver Ex Situ Perfusion: A paradigm shift in organ ex situ management
15:15-15:20 Welcome Introduction (Chairs)
15:20-15:40 The Temperature: Beyond the dualism Hypothermia vs Normothermia – Robert J Porte, Rotterdam, Netherlands
15:40-15:50 Ex Situ Liver Perfusion: Clinical ResultsIrene, Scalera, Bari, Italy
15:50-16:00 Inflammation Treatment in Liver Ex Situ Perfusion – Davide, Ghinolfi, Pisa, Italy
16:00-16:15 Final Discussion

Building the new standard of care – The OCS Liver Program

Grote Zaal, 1st Floor
Thursday, May 4, 15:15 – 16:15

1. The OCS Liver National OCS Program (NOP): structure and process –  Malcolm MacConmara
2. Experience and Outcomes from using the OCS Liver NOP – Gabe Schnickel
3. NOP: Expanding transplant center volume – single center experience – Amit Mathur
4. Transforming practices: benefits for the patient and the transplant center – Andrew Barbas
5. Beyond the first 1,000 OCS Livers NOP cases: what is next? – Magdy Attia
6. Q&A
*Moderators: Marwan Abouljoud and Liz Pomfret

Grote Zaal, 1st Floor
Friday, May 5, 12:30 – 13:30
Utilization of blood-based biomarkers in liver transplant patients; a step closer to personalized medicine

Eduard Flipse Zaal, 1st Floor
Friday, May 5, 12:30 – 13:30
Normothermic Perfusion: Why, When and How?
12:30 – 12:35 Symposium Open – Peter Friend, MD, FRC S, OrganOx Chief Medical Officer, OrganOx, Oxford, United Kingdom
12:35 – 12:50 Normothermic Perfusion: Why, When And How? – Stefan Shcneeberger, MD, MBA, FEBS (Director, Head of Transplantation surgery and Hepatobiliary Surgery, Innsbruck Medical University, Austria
12:50 – 13:05 Normothermic Perfusion: Why, When And How? – Dr Koji Hashimoto, MD, PhD, Cleveland Clinic, Ohio
13:05 – 13:20 Normothermic Perfusion: Why, When And How? –
13:20 – 13:30 Q&A Discussion and Symposium Close – Peter Friend, MD, FRC S

Eduard Flipse Zaal, 1st Floor
Friday, May 5, 13:45 – 15:00
Unlock the power of flexibility for liver perfusion
13:50-14:10 Implementing a successful machine perfusion program – The Munich experience – Dr. Moritz Drefs, LMU Klinikum Munchen, Munchen, Germany; Dr. Dionysios Koliogiannis, LMU Klinikum Munchen, Munchen, Germany
14:10-14:35 Machine perfusion, from cold to warm – The Groningen experience – Prof. Vincent de Meijer, UMC Groningen, Groningen, The Netherlands
14:35-14:55 Using ex-situ machine perfusion to test new therapeutics – Dr. Fotios Sampaziotis, University of Cambridge, Cambridge, United Kingdom
* Moderator: Prof. Umberto Cillo Università di Padova, Padova, Italy